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Nonetheless, because of the small numbers of events and of exposed patients (14 percent), we cannot draw firm conclusions about the role of cigarette smoking as a risk factor for thrombosis in this group of patients.
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This causes a particular form of anemia called hemolytic anemia.
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Only patients with moderate-to-severe disease who were age 18 and older were allowed to participate.
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July 11, 2008 -- Children with sickle cell disease often face severe pain, organ damage, recurrent strokes and repeated, prolonged hospital stays.
West African Journal of Medicine.
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This evolution is sufficiently rare (within what is already a rare disease), that the estimates of the risk are imprecise but are thought to be on the order of 1-2% of patients with ET over a lifetime.
This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis.
Clinical and Hematological Response to Hydroxyurea in a Patient with Hb Leporbp-Thalassemia.
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Hematopoietic Stem Cell Transplant (HSCT): Patients with severe disease refractory to current standard therapy (hydroxyurea), under the age of 17, or those with prior SCD related organ damage (eg, stroke, acute chest syndrome, frequent painful episodes, multiple sites of osteonecrosis) can be considered for HSCT.
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Her commitment to following her treatment plan and living a healthy lifestyle have helped her manage sickle cell anemia and live a happy, full life.
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None of the 21 patients had anemia, leukoerythroblastic findings on peripheral-blood smears, or systemic symptoms at trial entry, and only 1 (5 percent) had splenomegaly (as compared with 7 percent for the trial as a whole).
An interaction term, testing whether the effect of hydroxyurea changed with time, was assessed by Cox proportional-hazards models.
These may be appropriate first-line treatments for selected persons, including those who have not had a response to a trial of hydroxyurea.
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The effect of hydroxyurea on the rheological properties of sickle erythrocytes in vivo.
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Besides the conditions found in the general population, several conditions occur that are specific to sickle cell disease.
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American Journal of Medicine 90, 206-10.
Part of the process involves an abnormal immune response, which causes inflammation and rapid production of immature skin cells.
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In asymptomatic individuals with SCD, what is the effect of screening for renal disease, by measuring serum creatinine and urine albumin and protein, on mortality and the development of end-stage renal disease (ESRD)?
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Michael Terrin) enrolled 299 adult sickle cell anemia (Hb SS) patients who had experienced at least 3 painful crises in the previous year.
However, randomized controlled clinical trials of therapeutic phlebotomy for HCV treatment have not found significant improvements in sustained virologic response with phlebotomy plus interferon (IFN) compared to IFN alone (Fonatana et al, 2000; Di Bisceglie et al, 2000).
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Data are prospectively gathered on hydroxyurea pharmacokinetics, genotoxicity, and long-term effects on organ function.
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Maximum urine concentrating ability in children with Hb SC disease: Effects of hydroxyurea.
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In this view, among the patients with a past history of thrombosis, aspirin users should constitute a much higher percentage than that recorded in the retrospective analysis by Stefano et al.
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There was no difference in the marked reduction in urine concentrating ability in hydroxyurea-treated mice, compared to control mice ( Online Supplementary Figure S3).
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Incidence of neuropathy in HIV-infected patients on monotherapy versus those on combination therapy with didanosine, stavudine and hydroxyurea.
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Hydroxyurea (Droxia) is a drug that reduces the severity of sickle cell disease by stimulating production of HbF.
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Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.
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Our data support the use of hydroxyurea therapy for the prevention of painful crises in adult patients who are able to follow directions about dosages and monitoring and can appreciate the still unclear long-term risks of such treatment.
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